Studies on Antiulcer Agents. III. Synthesis and Antiulcer Activity of Phenylpropanol Derivatives
نویسندگان
چکیده
منابع مشابه
Phenoxypropylamines: synthesis and antiulcer evaluation.
We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, (1)H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of themshowed significant gastric acid antisecretory activity.
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Certain 2-(1'-iminothioimido substituted)-1'-substituted phenybenzoic acids (P(1-9)) were synthesized by reaction of phthalic anhydride with benzotriazole, 2-mercapto benzothiazole and 2-p-amino phenyl benzimidazole, respectively (A(1-3)) followed by imine formation with Schiff bases of thiourea with salicylaldehyde, furfuraldehyde and 1-phenyl-3-methyl-5-pyrazolone. Antiulcer activity was eval...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1995
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.115.4_307